What is presbyopia?
Presbyopia is the gradual loss of the eyes’s ability to focus on nearby objects. (1)
Presbyopia is a type of refractive error of the eye of a human.
Why does presbyopia happen?
When does presbyopia happen?
Presbyopia becomes noticeable in early to mid-40s and continues to worsen until around age 65. (1)
What new is presbyopia?
as of 6/11/2023 (for the past 60 days)
Visus Therapeutics reported positive results from the VIVID Phase 2 trial of three novel topical ophthalmic formulations for the treatment of presbyopia. The trial was a double-masked, randomized, dose-ranging, multicenter, three-arm crossover study designed to evaluate the safety and efficacy of fixed-dose combinations of carbachol and brimonidine tartrate (Brimochol and Brimochol F) compared to a similarly formulated preservative-free carbachol. The trial enrolled 85 subjects, ages 45 to 80, with emmetropic phakic and pseudophakic presbyopia at three U.S. sites.
In this study, a minimum of 83% of subjects treated with Brimochol, Brimochol F, or Carbachol F achieved the endpoint of 3 lines of improvement in binocular near visual acuity under mesopic conditions without losing 1 line of distance vision at 1 hour. A minimum of 82%, 52%, and 35% of subjects met this same endpoint at 3, 7, and 9 hours, respectively. All three formulations were well-tolerated with no unexpected adverse events. Adverse events exceeding 5% included temporary burning and stinging upon instillation, headache, and brow ache. No serious adverse events were reported.
Based on these positive outcomes, the company plans to commence phase 3 pivotal trials shortly. As it stands, drugstore reading glasses are the most common treatment option for people as they lose their near vision with age. The availability of a once-daily, preservative-free eye drop such as those evaluated in the VIVID study could attract millions of people into eye care practices nationwide, creating opportunities to not only improve visual performance but also advance eye health overall for this patient population.
The emergence of these eye drops as a potential treatment for presbyopia represents an important development in the field. Eye drops provide a non-invasive method of treatment that can improve near vision throughout the workday while avoiding the potential toxicity of preservatives【10†source】.
I attempted to find additional information on recent developments regarding ‘tunable lenses’ for the correction of presbyopia, but unfortunately, I was unable to access the relevant webpages at this time. I recommend checking reliable medical news websites or scientific journal databases for the latest information on this topic.
Resources
1. https://www.mayoclinic.org/diseases-conditions/presbyopia/symptoms-causes/syc-20363328
2. ChatGPT 4, 6/11/2023 “What has been learned new in the last 60 days about presbyopia?”
