What are nigrostriatal neurons?
Nigrostriatal neurons are a type of dopaminergic neuron located in the substantia nigra. (1)
Nigrostriatal neurons project their axons along a pathway called the nigrostriatal pathway, which goes from the substantia nigra to the striatum in the basal ganglia. (1)
The nigrostriatal pathway plays a crucial role in the regulation of movement. (1)
The loss of these specific neurons in the substantia nigra pars compacta is a hallmark of Parkinson’s disease, leading to the characteristic motor symptoms of this disorder. (1)
Where are nigrostriatal neurons located?
Nigrostriatal neurons originate specifically in the substantia nigra pars compacta (SNc). (2)
Resources
1. ChatGPT 4, 6/3/23, “Are the dopaminergic neurons that are located in the substantia nigra called something special?”
2. ChatGPT 4, 6/3/23 “Are nigrostriatal neurons located in both the substantia nigra pars compacts AND the substantia nigra pars reticulata?”
