What is the substantia nigra?
The substantia nigra is a region located in the midbrain that plays an important role in reward, addiction, and movement. (2)
Where is the substantia nigra located?
The substantia nigra is located in the midbrain. (1)

What does the substantia nigra contain?
The substantia nigra contains high levels of neuromelanin in dopaminergic neurons. (1)
The substantia nigra contains dopaminergic neurons. (3)
The substantia nigra contains nigrostriatal neurons. (4)

What happens if the substantia nigra degenerates?
Degeneration of the substantia nigra is associated with Parkinson’s disease. (1)

What are parts of the substantia nigra?
substantia nigra pars compacta (SNc) (2)
substantia nigra pars reticulata (SNr) (2)

Resources
1. ChatGPT 4, 6/3/23, “Where is the substantia nigra located?”
2. ChatGPT 4, 6/3/23, “What is the substantia nigra?”
3. ChatGPT 4, 6/3/23, “What type of neurons produce dopamine?”
4. ChatGPT 4, 6/3/23, “Are the dopaminergic neurons that are located in the substantia nigra called something special?”

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